SMILEs
STRUCTURAL MOLECULAR IMAGING LIGHT ENHANCED SPECTROSCOPIES

Single molecule imaging of double strand lambda DNA

Direct imaging of double strand lamda DNA

Details

The structure of the DNA double helix was accomplished in 1953, combining the analysis performed by Watson and Crick and the X-Ray diffraction images of DNA fibers made by Franklin and Wilkins in 1951. To date, the need to deepen the physical understanding of the DNA structure as well as its modifications and interactions drives the need of simplified sample treatment to the direct imaging of single molecules. To achieve this goal, we combined high-resolution imaging, superhydrophobic holed surfaces and fine tuned preparative steps and to get in depth functional and structural information at the single base pair level.